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Compared with psychostimulants, atomoxetine has a distinct mode of brain action and potentially lower addictive potential.
However identifying brain correlates of a situation-independent personality structure would require evidence of a stable default mode of brain functioning associated with the different personality dimensions.
"We find that the psychedelic state is associated with a less constrained and more intercommunicative mode of brain function, which is consistent with descriptions of the nature of consciousness in the psychedelic state," Expert and colleagues conclude.
"We speculate, post hoc, that large doses of psychedelics might induce an ultra-flexible mode of brain functioning but a breakdown of more rational processes, while microdosing might drive brain functioning towards an optimal balance between persistence and flexibility".
They are considered to reflect a default mode of brain function [4] and to constitute a default-mode network (DMN) [5].
In this regard, the accumulating evidence for the existence of a default mode of brain function has derived from the observation of intrinsic activity in a neural architecture encompassing regions of the MPFC, PCC and medial precuneus [15], whose interaction would be intimately involved in self-awareness and conscious experience [16] [18].
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Differences between more global modes of brain functioning, perhaps ones that activity of more discrete neural systems of special interest cause or enter into, may better fit the intuitive difference between pleasure and pain.
Integrated states enable faster and more accurate performance on a cognitive task, and are associated with dilations in pupil diameter, suggesting that ascending neuromodulatory systems may govern the transition between these alternative modes of brain function.
The benefits of neuromodulatory procedures as a possible therapeutic application for cognitive rehabilitation have increased with the progress made in non-invasive modes of brain stimulation in aged-related disorders.
The linear relationship between steady-state and transients suggests that they do not constitute two different modes of brain response.
In what follows, we will consider the coupling of two macroscopic modes of brain activity, which, in a purely descriptive fashion, we will label as cognitive and emotional modes.
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