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Since our model is purely based on cis-regulated altenative splicing, the relative importance of this mode of alternative splicing is an important, yet still unresolved question.
As is well known, the mode of alternative splicing differs among various tissues [32], [33], and our MyoD-transduced fibroblasts might have characteristics that are incompatible with the alternative splicing of exon 9.
Intron retention is considered the prevalent mode of alternative splicing in plants [ 42, 43].
Intron retention is one basic mode of alternative pre-mRNA splicing in plants and eukaryotic cells.
Alternative selection of splice sites in tandem donors and acceptors is a major mode of alternative splicing.
A hypothesis of the mode of alternative splicing was formulated based on exon array expression profile and available transcript annotations.
Similar(51)
Since our grouping of genes only relies on the observed number of splicing patterns through ESTs, we do not distinguish between different modes of alternative splicing.
There are numerous modes of alternative splicing, and they have greatly increased the range of proteins that can be encoded [1].
Constitutive and regulated modes of alternative splicing exist for DMPK pre-mRNA and result in the expression of six major DMPK splice isoforms, conserved between mouse and man.
The modes of alternative splicing are diverse in the clock genes.
Fourth and consistent with the above observation, the level and modes of alternative splicing in Amphimedon is more akin to those found in yeast than in other animals.
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