The fact that we do indeed recognize distinct modes of acute and chronic toxicity, and that agents cause different outcomes from short and prolonged exposures, argues against the generality of the needed assumptions for additivity to background (Rodricks et al., 2007).
Our work highlights the fact that diverse modes of acute liver injury have differing requirements for RIP1 and RIP3; moreover, within a single injury model, RIP1 and RIP3 blockade can have diametrically opposite effects on tissue damage, suggesting that interference with distinct components of the necrosome must be considered separately.
We identified MTP derivative 1 with high antitrypanosomal potency and curative efficacy in an animal model of acute trypanosomiasis and investigated its mode of action.
However, whether the decay rate of beta cell function is relevant with the mode of onset (acute or latent-onset) is unclear.
However, depending on the route of ingestion, dose, valence state, mode of exposure (acute versus chronic), and the age of the individual the heavy metals can cause varying degree of toxicity.
The nature and severity of toxicity vary with the heavy metal involved, its exposure level, chemical and valence states (inorganic versus organic), mode of exposure (acute versus chronic), and the age of the individual.
Considerable information supports involvement of VSSCs in the mode of action of acute pyrethroid neurotoxicity, yet the potential role of VSSCs in developmental neurotoxicity of pyrethroids has not been examined.
* OR: odds ratio in logistic regression mode = (number of acute dengue/number of no acute dengue, among presumptive diagnosis)/(number of acute dengue/number of no acute dengue, among all other diagnoses) Of the 45 cases that were clinically diagnosed as acute dengue, 22 were serologically confirmed (48.9%).
The most common mode of presentation was acute in 182 (71.1%) patients, followed by sub-acute and chronic presentation in 47 (18.4%) and 27 (10.5%) patients respectively.
The mode of onset was acute in five patients, thunderclap in one, and gradual and progressive in one.
