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This complex binding mode may explain the lower than expected significance of SMAP hits for known H3P targets, as the template for the binding site used for the SMAP screen did not capture the six-molecule ring binding mode.
Phagotrophy is widespread in chromalveolates and excavates therefore this feeding mode may explain an increased rate of HGT in these taxa [ 11, 52, 72, 77]; i.e., many extant species of excavates and chromalveolates feed on bacterial and eukaryotic microorganisms [ 78- 82].
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A ({Y_{2}^{0}}) CMB heat flux pattern combined with internal heating may trigger an unstable odd convective mode which may explain the hemispheric field of Mercury (Cao et al. 2014; Wicht and Heyner 2014) as observed by MESSENGER (Anderson et al. 2012).
The favourable entropic component of binding of the lead series may reflect a disordered binding mode and may explain the difficulties in obtaining a crystal structure in complex with the protein.
This mode of action may explain the suggested role of this metalloid in the etiology of certain neurodegenerative and age-related disorders associated with arsenic poisoning.
In addition, because the mechanisms of cartilage degradation in OA are multifactorial and some nutritional compounds (such as plant extracts) usually contain multiple active compounds that target multiple pathways, nutrition could provide an alternative to pharmacological interventions whose often monomodal mode of action may explain their partial lack of clinical efficacy in OA.
These data suggest that TSC1/2 may be in a more active mode following ablation and may explain the inhibitory effect of AMPKα1.
The discussed studies, in which interventions in Wnt signaling following MI are described (Table 1), have different modes of treatment that may explain the discrepancy in the outcomes.
This factor may explain the hybridization mode of Single Bond Universal, which may apply surfactant technology that was previously noted in a patent from the 3 M ESPE Corporation [26].
The phenomenon may explain why the mode conversion due to the chirality is particularly enhanced between the first and second transition frequencies.
This may explain why wave mode with c x = 100 m/s produces larger dynamical effects and stronger wave-induced jet at high altitudes than the mode with smaller c x. Increased mean flows combined with superimposed wave structures (see Figure 7c) may produce narrow layers with large vertical wind shears.
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