Sentence examples for mode distinct from from inspiring English sources
Here we present the 2.8 angstrom crystal structure of a complex between human IL-2 and IL-2Ralpha, which interact in a docking mode distinct from that of other cytokine receptor complexes.
More importantly, the structures reveal a 3D fold and a GTPase-recognition mode distinct from those of all known GAPs.
The fact that stickleback and cod share an evolutionary mode distinct from other investigated teleosts spurred us to look for more similarities between cod and stickleback.
However, in the absence of transposon ends, the drug adopts an unusual, compact binding mode distinct from that observed in the active site of the prototype foamy virus integrase.
Other groups have used peptides in this regard, but predominantly in an analytical or imaging mode distinct from long-term goal of reducing thrombus size using cross-linkable proteins.
Crystal structures of LepB313-618 andne and the GAP domain of Legionella drancourtii LepB in complex with Rab1-GDP-AlF3 support the catalytic role of Arg444, and also further reveal a 3D architecture and a GTPase-binding mode distinct from all known GAPs.
Our integrated analyses reveal that half of the marketed drugs and most of the drugs in clinical trials that interact with peptide GPCRs are small molecules with a wide range of binding modes distinct from those of large peptide ligands.
The SH parameters of the coordination mode are distinct from, but similar to, those of component I coordination mode of Cu2+/Aβ1 16 (Table 2).
These results do not exclude the involvement of the many other lysosomal hydrolases in the cytotoxicity of Mtb but they establish that this death mode is distinct from pyronecrosis and does not depend on lysosomal proteases typically linked to cell death.
The observed binding mode appears distinct from other single motif binding interactions, as well as from mechanisms that involve global conformational transitions, such as folding upon binding (Csermely et al., 2010; Wright and Dyson, 2009).
However, we do not observe the P+0 residue in any of our structures, which leaves open the possibility that the observed binding mode is distinct from that of true substrates.
