Theoretically, identification and characterization of the CSCs may allow the development of treatment modalities that target the cancer stem cells rather than the rapidly dividing cells in the cancer.
Preservation of the breast cancer microenvironment is critical for evaluating therapeutic agents especially when designing modalities that target invasive disease.
Given the importance of inflammatory pathways in HF, new treatment modalities that target inflammatory mediators may be effective.
It is becoming clear that combination or sequential treatment modalities that target multiple pathways can lead to better control of aberrant cell proliferation.
It is crucial to develop clinically relevant novel combination regimens involving synergistic modalities that target a wider repertoire of cells and lead to lowered individual doses.
Our results show a marked defect in DDR activation with DMC1 depletion and combination of a DMC1 inhibitor with treatment modalities that target various DNA repair pathways could effectively target GBM cells.
The challenges before us are, on one hand, to discover novel treatment modalities that target essential steps that are involved in the development of IBC, such as those directed against its angiogenic and angioinvasive potential.
The above mentioned actions of MMPs encouraged us to develop a molecular imaging modality that specifically targets MMP molecules.
Oncolytic vaccinia virus (VACV) therapy is an alternative cancer treatment modality that mediates targeted tumor destruction through a tumor-selective replication and an induction of anti-tumor immunity.
