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Overall, these data underline the capacity of the nanocarriers to overcome substantial barriers associated to the oral modality of administration and to facilitate the accumulation of the associated peptide at the intestinal level.
The objective of this work was the development of a new drug nanocarrier intended to overcome the barriers associated to the oral modality of administration and to assess its value for the systemic or local delivery of peptides.
Indication for sodium lactate, dose, and modality of administration were collected.
The unattended modality of administration was consequently deemed valid for clinical use.
To date, there is still no consensus on its optimal dose, modality of administration, and treatment time.
Finally, the tolerability of citicoline has never constituted a problem whatever the modality of administration or the dosage.
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Novel modalities of administration are under investigation such as; aerosol, intratumoral and intravascular.
We aimed at studying MDPV-related neurobehavioral effects according to various modalities of administration, mimicking human uses.
We investigated the factors associated with the prescription of aminoglycosides started between day 1 and day 3 of admission, and we studied the modalities of administration of aminoglycosides.
It should be noted that only one of these studies took into account MICs [20], whereas none took into account dosages and modalities of administration for assessing the effectiveness of therapy [19].
Besides, improvements in the use of already available drugs are still possible (e.g., piperacillin tazobactam for ESBL-PE with low MICs, or colistin for carbapenem-resistant GNB), both when indications and modalities of administration (including therapeutic drug monitoring) are considered.
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automation of administration
procedure of administration
format of administration
methodology of administration
type of administration
form of administration
way of administration
means of administration
modes of administration
modality of treatment
modality of change
modality of monitoring
modality of communication
modality of interest
modality of exercise
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