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Further, the use of combined modality approaches in pancreatic cancer is associated with increased gastrointestinal toxicity [ 16].
The majority of patients included in current study were not, however, candidates for combined modality approaches, in particular to curative therapy (as clearly specified by the inclusion criteria).
The European Organisation for Research and Treatment of Cancer (EORTC) Head and Neck Cancer Group (HNCG) has offered major contributions in the field of combined modality approaches in locally advanced disease [ 9– 13].
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Thus, while we view the combination of capecitabine and radioembolization as safe in this conservatively defined patient population, caution may be warranted in the utilisation of this combined modality approach in patients with mildly compromised liver function.
Furthermore, this study emphasises the importance of considering multi-modality approaches in optimising the therapeutic ratio and draws attention to the importance of vascularity and endothelial cell interactions with radiosensitivity.
Neo-adjuvant chemotherapy (NACT) is an integral part of multi-modality approach in the management of locally advanced breast cancer (LABC).
Neo-adjuvant chemotherapy is an integral part of multi-modality approach in the management of locally advanced breast cancer and it is vital to predict the response in order to tailor the regime for a patient.
Combined modality approaches have been developed in an effort to enhance loco-regional disease control, reduce distant metastatic spread, and improve survival in patients with inoperable head and neck cancer [ 6- 8].
In our experience, combined modality approaches generally provide high local RC rates but are associated with suboptimal functional outcomes.
In view of the resistance of MPM to single modality approaches, multimodal therapeutic strategies have been proposed.
This combined modality approach produced an absolute increase in 5-year survival of 12% as compared with radiation therapy alone and resulted in a sudden change in the standard of care for this disease.
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