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This dual-imaging modality approach provides a better understanding of the underlying disease by fusing both modalities into a single view.
A combined modality approach (preoperative cisplatin-based chemotherapy, surgery and radiotherapy) hase been shown to increase cure rates in stage IIIA NSCLC from 10 15% to 25 40%.
This phase I/II trial was designed to determine the maximally tolerated dose of thoracic radiotherapy as part of a combined modality approach.
Current standard treatment includes surgical resection followed by radiation with concurrent and adjuvant temozolomide as part of a combined modality approach.
We now raise the question whether both rituximab and RIT should be used together as complementary methods to augment the results achievable with chemotherapy and whether this combined modality approach might afford additive or synergistic benefit.
Taken together, the most effective use of lovastatin and VEGFR-TKI would be as part of a combined modality approach.
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Further, the use of combined modality approaches in pancreatic cancer is associated with increased gastrointestinal toxicity [ 16].
In our experience, combined modality approaches generally provide high local RC rates but are associated with suboptimal functional outcomes.
In view of the resistance of MPM to single modality approaches, multimodal therapeutic strategies have been proposed.
The majority of patients included in current study were not, however, candidates for combined modality approaches, in particular to curative therapy (as clearly specified by the inclusion criteria).
There is no consensus on the management of locally advanced pancreatic cancer, with either chemotherapy or combined modality approaches being employed (Maheshwari and Moser, 2005).
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