The introduction of combined modality trials will require a very prolonged follow-up to demonstrate improved survival and recognize late onset of chronic toxicity.
Given the fact that disease-associated EMT is of two types, it becomes more complicated to tease out what proteins/pathways are contributing independently to fibrosis and cancer and what therapeutic modalities will they require since BOTH types share the EMT proteome, but empirically seem to differ only in the neo-angiogenesis component.
More importantly which proteins/pathways are amendable to current therapeutics and which will require new modalities of interaction are not clearly understood.
Improving outcomes in stem cell transplant recipients will require additional therapeutic modalities for GVHD, especially for those patients who fail to respond to initial therapy with steroids.
Additional treatment modalities will be required for a proportion of these adolescents.
In this review, we will discuss current findings to support the hypothesis that in most scenarios, combination with other therapeutic modalities will be required to optimise efficacy and current evidence for the molecular mechanisms that underpin potential combinations.
Comparative trials, in which cohorts of patients undertake qigong versus exercise, or qigong versus mind-body modalities, will be required in order to ascertain whether qigong produces benefits that differ from these other approaches.
These efforts will require greater integration between different research modalities, including genetics, psychopathology, and cognitive and affective neuroscience, together with insights from systems biology.
Nevertheless the presence of a high quantity of the biomaterial particles after 6 months will require long-term histological studies to better understand the times and the modalities of the resorption of this graft.
To rein in spending, therefore, we will require better knowledge about the effectiveness of existing and emerging diagnostic and treatment modalities, along with an appropriate system of accountability.
