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Future treatment modalities include molecular targeted therapies.
Adjunctive treatment modalities include lifestyle/behavioral/pharmacologic measures.
Many integrative modalities include a physical activity component.
Biomarker modalities include molecular, histologic, radiographic, or physiologic characteristics.
Treatment modalities include medication management and comprehensive behavioral interventions for tics (CBIT).
Adjunctive treatment modalities include lifestyle or behavioral measures and pharmacologic therapy.
Failures to these treatment modalities include inherent resistance, systemic toxicity and severe side effects.
Other screening modalities include first trimester screening, second trimester quad screening, serum integrated screening, and NT-Quad.
The biomarker modalities include plasma/serum/exosomal and cerebrospinal fluid molecular biomarkers, brain tissue molecular biomarkers, imaging biomarkers, electrophysiologic biomarkers, and behavioral/cognitive biomarkers.
The most promising treatment modalities include blocking of the renin-angiotensin system (RAS), activation of peroxisome proliferator-activated receptors gamma (PPAR-γ), influence on the remaining PSC signaling pathways, blocking of substances produced by activated PSCs, and antioxidants.
Imaging modalities include CT and MRI.
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