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Nanoparticle-based drug delivery platforms are emerging as powerful chemotherapeutic modalities in breast cancer.
Radiotherapy is one of the major modalities in breast cancer treatment.
Thus, the anti-angiogenesis therapy has become one of the most important modalities in breast cancer treatment.
Whether HER-2 status is a predictor of response to other treatment modalities in breast cancer, namely hormonal and cytotoxic therapy, remains contentious.
In recent years, several improvements in medical treatment modalities in breast cancer were observed; [ 4, 17- 19] however, the overall prognosis and predictive values for breast cancer patients remains ambiguous [ 5, 6].
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Inhibitors of this pathway could represent a new therapeutic modality in breast cancer, perhaps through combination with current treatments.
Because of its superior sensitivity for the detection of invasive breast cancer, MRI has become a very important modality in breast imaging [ 2– 5].
Mammography is still the main imaging modality in breast cancer with sensitivity between 69 and 90% and the specificity ranging from 10 to 40% (Rankin, 2000).
We uncover two types of potential gene switches in breast cancer, with one type (denoted as Type 1) showing bimodality within the breast cancer and a second type (denoted as Type 2) showing predominantly one modality in breast cancer.
We propose that the IL-6/gp130/Jak IL-6/gp130/Jakway playsignalingcal role in Stat3 activation in human breast cancer and that blockade of this pathway may be an implaysnt therapeuticriticalty in brolet cancer.
It is clear that whereas endocrine therapy represents a crucial modality in breast cancer management, with substantial success to date, there is still much to be learned and great potential for increasing its value to patients.
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