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Selecting appropriate treatment modalities for metastatic RCC remains a challenge.
In view of the limited success of available treatment modalities for metastatic breast cancer, alternative and complementary strategies need to be developed.
Since treatment modalities for metastatic recurrent triple-negative breast cancer (mrTNBC) are limited, a novel treatment approach including immunotherapy is required.
For the purposes of comparison, the reported relevant clinical outcome measures for a range of different published treatment modalities for metastatic melanoma are shown in Table 2.
To develop new and alternative therapeutic modalities for metastatic disease and to investigate the metastatic progression and the molecular genetics of RCC, various pre-clinical animal models were established (reviewed in ref 6).
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Tumor to normal tissue ratio (T/N ratio) is a useful metabolic parameter to differentiate tumor recurrence from radiation necrosis after gamma knife radiosurgery (GKR) [2], which is an important treatment modality for metastatic brain tumors [4].
It has been shown that FDG PET is an excellent imaging modality for metastatic evaluation with the exclusion of the brain.
Early small reports on the increased sensitivity and specificity of MR and specifically whole-body MR over RNB may point to greater use of this modality for metastatic bone involvement.
This combination may become the foundation for a feasible cancer treatment modality, particularly for metastatic cancers.
In the MD Anderson review greater than 5% of the patients who underwent resection were found not to have osteosarcoma metastases 4. The most frequently used modality for defining metastatic disease is the visualization of nodules on computed tomography (CT) of the chest.
We found little if any difference in outcome between treatment modalities for men with metastatic prostate cancer in our main analyses, although sensitivity analyses indicated a possible benefit for radiotherapy.
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