The resolution is the highest of the three 3D modalities, approaching the limit of resin-embedded sections: the glycocalyx was clear and the fibre spacings discernible, but the missing angles in the tilt series were a limiting factor in the z direction.
Similarly, other multi-modality approaches such as PET/MRI are under development to increase the spatial and temporal resolution of the PET and the sensitivity of MRI [68].
For patients with locally advanced disease, multi-modality approaches incorporating adjuvant or neoadjuvant chemotherapy and radiation therapy need to be studied.
However, CRF often persists precisely because its complex etiology renders mono-modality approaches limited [ 23].
Further, the use of combined modality approaches in pancreatic cancer is associated with increased gastrointestinal toxicity [ 16].
In our experience, combined modality approaches generally provide high local RC rates but are associated with suboptimal functional outcomes.
In view of the resistance of MPM to single modality approaches, multimodal therapeutic strategies have been proposed.
The majority of patients included in current study were not, however, candidates for combined modality approaches, in particular to curative therapy (as clearly specified by the inclusion criteria).
There is no consensus on the management of locally advanced pancreatic cancer, with either chemotherapy or combined modality approaches being employed (Maheshwari and Moser, 2005).
Advantages in surgical techniques, radiation therapy techniques, chemotherapeutic regimes, and different combined-modality approaches have yielded only a modest impact on the prognosis of patients with pancreatic cancer.
