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In this paper, we use correspondence theory for modal logics to solve a problem not addressed yet in the literature, namely the soundness and completeness of a logic combining two different, yet related modalities: agents' knowledge and commitments.
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With the current rapid growth of hybrid PET/MRI systems in diagnostic radiology, our molecular design of dual-modality agents possessing a "single pharmacological behavior" offers a versatile platform for the development of multimodality imaging agents with potential applications for noninvasive molecular profiling of various diseases.
To take advantage of the strengths of PET and MRI, our approach is to design and synthesize a dual-modality agent scaffold offering a "single pharmacological behavior" for both imaging acquisitions.
James, M. L. & Gambhir, S. S. A molecular imaging primer: modalities, imaging agents, and applications.
James M. A molecular imaging primer: modalities, imaging agents, and applications.
The different classifications are summarized into the following categories, deducted from the American Physical Therapy Association's (APTA) Guide to Physical Therapist Practice [ 23]: therapeutic exercises; functional training in work; manual therapy techniques; prescription, application, fabrication of devices; electrotherapeutic modalities; physical agents and mechanical modalities; and other.
Using standard click reaction conditions, we successfully synthesized three different dual-modality imaging agents with the same precursor (Fig. 3b).
The clickable bimodal imaging tracer is then conjugated in a bioorthogonal cycloaddition reaction to various peptides, yielding dual-modality imaging agents quickly via a modular synthetic protocol.
Two major challenges in the development of dual-modality imaging agents are the usually increased synthetic complexity and the effect of the fluorescent dye on the biodistribution of the imaging agent.
In conclusion, this study clearly confirms that FMNP-labeled MSCs could target gastric cancer cells in vivo and could be used as dual-modality contrast agents for in vivo gastric cancer's fluorescent imaging and magnetic resonance imaging.
Using the previous described click chemistry approach, we attached successfully 18F-BODIPY-azide 2 to various peptides, such as exendin-4, pHLIP, and CCK2 and obtained three different peptidic dual-modality imaging agents: Analytical data for 18F-BODIPY-CCK2: t r = 14.7 min; ESI-MS: m/z = 1134.2 (100) [M + Na + H]2+.
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