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Starvation-induced hypothalamic autophagy is shown to mobilize neuron-intrinsic lipids to generate endogenous free fatty acids, which in turn regulate AgRP levels.
Previous work by others and us had shown that tonicity levels of 380 420 mOsm/kg were sufficient to mobilize NFAT5 in neurons [42] and lymphocytes [25], and inhibited the proliferation of NFAT5-deficient lymphocytes [24].
The induction of autophagy in hypothalamic neurons during starvation mobilizes neuronal neutral lipids to generate neuron-intrinsic free fatty acids that serve to upregulate fasting-induced AgRP levels.
L1 retrotransposons mobilize extensively in hippocampal neurons, preferentially in hippocampally expressed loci, and are depleted from mature neurons when oriented in the most deleterious configuration to host genes, suggesting functional significance.
Epac has been shown to activate p38 kinase and mobilize intracellular calcium in neurons[ 39].
Previous experiments have shown that spiral ganglion neurons (SGNs) may mobilize XPA as a general stress response to chemical and physical ototoxicants.
Due to the lack of precise information on the physical coupling between cultured neurons as well as on the nature of calcium stores that are effectively mobilized in embryonic neurons [25], we can only speculate on that issue.
We show that the FLP-7 peptide is secreted from neurons, and acts in the intestine via the tachykinin 2 receptor orthologue NPR-22 to mobilize fat stores (Fig. 8b).
Cisplatin is known to damage spiral ganglion neurons at the basal coil of the cochlea therefore it was posited that cisplatin may target their DNA and mobilize XPC and XPA.
Different groups will mobilize.
"We will mobilize millions of Burmese".
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