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The growth factor administration resulted in a mobilization of progenitor and stem cells into the peripheral circulation and in an up-regulation of anti-apoptotic genes.
Mobilization of progenitor cells from the BM is complex and is based on the interplay of different factors.
Since this early restitution is not based on cellular proliferation but on migration, mobilization of progenitor cells is not required.
We found that G-CSF modulated vascular repair through the mobilization of progenitor cells from bone marrow into the peripheral blood.
Many of these pathological conditions require rapid response of the bone marrow and mobilization of progenitor cells that contribute to tissue repair.
To our knowledge, LDI had several biologic effects of increasing expression of vascular endothelial growth factor (VEGF) and mobilization of progenitor cells [ 7, 8].
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Increased mobilization of progenitors from the bone marrow in response to these factors may be an explanation for improved repair that has been observed in models of wound healing, cardiac myocyte injury, and endothelial denudation.
In addition, activation of Akt signalling stimulates the proliferation and inhibits apoptosis of endothelial progenitor cells cultured under high-glucose conditions and importantly increases ischemia-induced mobilization of endothelial progenitor cells [10].
This factor might induce neointimal vulnerability by mobilizing smooth muscle progenitor cells during the early phase of vascular repair and it also accelerates reendothelialization, possibly via the mobilization of endothelial progenitor cells and the promotion of vascular healing after injury during the later phase.
Postnatal vasculogenesis is mediated by mobilization of endothelial progenitor cells (EPCs) from bone marrow and homing to ischemic tissues.
Boulad, F. et al. Safety and efficacy of plerixafor dose escalation for the mobilization of CD34+hematopoietic progenitor cells in patients with sickle cell disease: interim results.
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