Sentence examples for mobilization of leukemic from inspiring English sources

A number of reasons could explain preferential mobilization of leukemic clones.

In pre-clinical in vivo leukemia models, directed inhibition of CXCR4 resulted in mobilization of leukemic cells into circulation.

No differential mobilization of leukemic cells was seen when plerixafor was used as a single agent, indicating the likely role of G-CSF in the observed phenomenon.

37 Plerixafor should not be used in leukemia patients because the drug may potentially cause mobilization of leukemic cells and subsequent contamination of the apheresis product.

These results and those showing a decrease in leukemic cell numbers in the BM of treated mice indicate that CXCR4 inhibition is associated with a mobilization of leukemic cells from the BM to blood.

Functional analysis showed a greater mobilization of leukemic cells and LICs in response to drugs, suggesting that they target the interaction between leukemic cells and their supportive bone marrow microenvironment.

Deregulated cell motility, e.g. in leukemic precursors, can lead to i). an abnormal mobilization of early leukemic precursors into the peripheral blood; ii). a leukemic infiltration of extra-medullar tissues; and iii).

First, we showed that chronic or acute administration of these drugs results in a rapid mobilization of bulk leukemic cells and progenitors into the blood.

Treatment with G-CSF plus plerixafor might induce a proliferation or differentiation effect with mobilization that results in preferential expansion of leukemic cells in peripheral blood.

Alternatively, more leukemic clones might occupy the bone marrow leading to greater numbers of leukemic cells being mobilized over time.

To determine whether common molecular pathways mediate such shared HSC responses during differentiation, mobilization, and leukemic transformation, we next performed a meta-analysis of the differentially regulated genes from these three pairwise comparisons.