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Exact(22)
These findings do not point to substantial mobilization of lead from cortical bone during menopause.
The observed changes are considered to reflect increases in mobilization of lead from the skeleton despite calcium supplementation.
Sources of maternal lead can be extrinsic (maternal environmental exposure) or intrinsic (via mobilization of lead in bone stores).
149 Blood lead levels may reflect current environmental lead exposure and may also reflect mobilization of lead from bone.
Further, EDTA treatment can result in mobilization of lead from hard tissue deposit to soft organs [ 157, 158].
The changes in lead isotopic composition and lead concentration are consistent with a decrease in bone resorption and associated mobilization of lead during alendronate therapy.
Similar(38)
Hence, by monitoring migrant subjects who conceive after arrival in Australia, it is possible to detect changes in isotopic composition and lead during pregnancy and the postpartum period arising from increased mobilization of skeletal lead.
Thus, patellar lead would be expected to exert the greatest impact on BP if the mechanism required only mobilization of bone lead stores during pregnancy.
Although there has been a substantial decline in lead exposure in the United States during the past couple of decades (Pirkle et al. 1994), mobilization of existing lead stored in bone potentially represents an important endogenous source of exposure.
During pregnancy, the mobilization of bone lead increases, apparently as the bone is resorbed to produce the fetal skeleton (Franklin et al. 1997; Gulson et al. 1997a, 1998b; Manton 1985).
The patella is composed mostly of trabecular bone, which has a higher reabsorption rate and is considered the major skeletal source of circulating lead (Hu 1998); thus, patella bone lead would have been expected to exert the greatest impact on PP if the mechanism of that impact required mobilization of bone lead stores.
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