Sentence examples for mobilization in human from inspiring English sources

Though evidence of monocyte mobilization in human disease has now been demonstrated, the question of whether their rise is consequential of the illness/inflammation or directly contributes to the inflammatory process remains largely unanswered.

ANF also inhibits glycolysis, increases gluconeogenesis in the rat liver (Rashed et al, 1992), and regulates lipolysis and lipid mobilization in human adipocytes (Sengenes et al, 2000).

We also found that IL-1β blockade can substantially reduce macrophage-stimulated release of the proinflammatory cytokines and lipid mobilization in human adipocytes, which could provide a mechanistic link between IL-1β and insulin resistance at local and also systemic levels.

It has been shown recently that the markers of macrophage infiltration positively correlate with the rate of lipolysis in human adipocytes isolated from abdominal fat (34); however, little is known about whether IL-1β is responsible for macrophage-induced lipid mobilization in human adipose tissue.

CER-001, an HDL-mimetic made up of apoA-I and phospholipids, has been associated with reduction of vascular inflammation and atherosclerotic regression after short-term administration in mice (Tardy et al, 2014) as well as cholesterol mobilization in humans.

Myocardial energetics is directly related to [Ca2+]i and mobilization in failing human myocardium, because metabolites, e.g., ADP, inhibit pumps, such as sarcoplasmic reticulum Ca2+ ATPase activity.

Consistent with this, PCI-32765 dose-dependently inhibited calcium mobilization in primary human B lymphocytes as described in the literature correlating Y551 and calcium mobilization following BCR activation [ 33, 34].

Characterization of Alu mobilization in non-human primates has not been as complete.

There is emerging evidence indicating that variation in the human SDF1 gene can have an influence on SDF1α levels[28], [28], which was demonstrated clearly to be involved in progenitor cell mobilization and differentiation in human and animal studies.

Similarly, in cell-based bioassays, VEGF Trap inhibited the activation of VEGFR1 and VEGFR2, as well as VEGF-A induced calcium mobilization and migration in human endothelial cells more potently than ranibizumab or bevacizumab.

Consistent with its higher affinity for VEGF-A and faster association rate, VEGF Trap demonstrates increased potency relative to ranibizumab and bevacizumab in blocking VEGF-A induced activation of VEGFR1 and VEGFR2 in cell-based assays, and also in blocking VEGF-mediated calcium mobilization and migration in human endothelial cells.