Sentence examples for mobilization effect from inspiring English sources
Moreover, the concurrent inhibition of VLA-4 and CXCR-4 has a synergistic mobilization effect in primates [ 104 ].
This mobilization effect in CEP levels may facilitate tumor cell repopulation during the common time intervals between the individual chemotherapy cycles [ 33].
Of note, the mobilization effect of CXCR4 antagonists was not limited to CXCR4high cases, suggesting that blockage of CXCR4 is not the unique reason for AML cell mobilization.
Studies in mice, primates, and humans have shown that the administration of the anti-VLA-4 monoclonal antibody (natalizumab) or blockade of its ligands leads to a potent mobilization effect [ 23, 28, 58 ].
Several DM patients have been treated with high-dose hrG-CSF in cell therapy protocols (31), but a formal comparison of the mobilization effect between DM and non DM patients never has been performed.
11– 16 Further, plerixafor synergistically augments the mobilization effect of G-CSF on CD34+cells. 5 Hematopoietic differentiation of transplanted CD34+cells was similar after plerixafor or G-CSF mobilization methods.
When given in combination, G-CSF plus plerixafor are synergistic in mobilization effects.
Finally, no correlation was found between plerixafor dose escalation and mobilization effects on WBCs, blasts, CD34+ cells, or FISH+ cells (Supplementary Table 11).
This may represent continued effect of G-CSF plus plerixafor, mobilization effects of chemotherapy, or slow kinetics of busulfan-induced myelosuppression, which occurs in a time-dependent fashion, and possibly in an apoptosis-independent fashion.
To evaluate the contribution of Ca2+ release from intracellular stores to CCh-induced [Ca2+]i mobilization, the effect of Ca2+ store depletion was tested.
Understanding the mechanisms behind this "mobilization position effect" will likely require an increased understanding about molecular regulators of SB transposition, but may include a well known director of position effect, heterochromatinization [ 30].
