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The topography did not affect the mobility of focal adhesions.
On all the surfaces that we have tested, we observed a mobility of focal adhesions.
We conclude that on the material surfaces that we have studied a reduced mobility of focal adhesions may strengthen the linkages between cell and ECM but impair the ability to dynamically organize and remodel the ECM.
Similar(57)
Single particle tracking reveals the dynamics of individual TGFβ receptor molecules, and identifies populations of TGFβ receptors with distinct behaviors and mobility near and far from sites of focal adhesions.
Strong influence on the formation of focal adhesions, reorganization of cytoskeleton, and change in the mobility were observed [12].
There was no evidence of secondary pathology (such as clamped fins or reduced mobility) among focal fish at this time.
Experimental methods for the determination of macromolecular diffusivity, as fluorescence recovery after photobleaching (FRAP) or single particle tracking (SPT) determine diffusion on the basis of apparent mobility within the focal depth, about 600 nm thick, which is in the range of the thickness of a single mitochondrion.
On these surfaces we observed a 25% increase in the number of focal adhesion points and a similar decrease in the degree of nuclear deformation, both phenomena associated with decreased mobility.
The therapy of focal epilepsy remains inadequate.
The findings are indicative of focal pyelonephritis.
Pleural TB? Presence of focal liver lesion?
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