In summary, Swi6 is highly mobile throughout the nucleus, exchanging between different heterochromatic domains via the nucleoplasm.
In mammals, experimental studies have shown that Double Strand Breaks (DSBs) are not mobile in the nucleus [ 19, 20].
During these chaotic divisions the cell morphology changes dramatically: the cell size increases, the cytoplasm is stretched and less mobile, and the nucleus enlarges.
Consistent with this hypothesis, our unpublished studies and another report (Muyan et al., 2012) have shown that in the absence of ligand, the ERβ protein appears less mobile within the nucleus than ERα suggesting that ERβ is already bound to chromatin regardless of the presence of ligand.
The mobile nucleoporin Nup153 shuttles between nuclei and the cytoplasm, at steady-state the protein is concentrated at the nuclear envelope (Fig. 4).
When cells' treated with either 17βE2 or tamoxifen prior to ATP depletion the ERα was less mobile, more prominent in the nucleus and reduced the shuttling to the cytoplasm [42].
Further mobile single molecules within the nucleus or the cytoplasm (black arrows) can be recognized as diffraction-limited bright spots.
Upon analyzing the fluorescence microscopy images it was noticeable that bright mobile spots moved centrally towards nucleus under the influence of simulated microgravity.
Many important recrystallization texture components in metals such as aluminium originate from nuclei in which the mobile high-angle boundary exists prior to, or is formed in the early stages of, annealing.
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