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Additional elements -- RGPmob and RGPnone elements -- lacking classical mobility features may be hypervariable regions that undergo deletions, ancient mobile elements with a degraded mobilization machinery, MGE that can be mobilizable in trans by other MGEs or non canonical MGE for which the mobility mechanism has yet to be described.
Mobile elements with CRISPR containing spacers matching the host chromosome could have highly deleterious effects.
By sequence homology this human-specific insert belongs to the Yi6 sub-group of Alu (Figure S2), a primate-specific family of short interspersed mobile elements with over one million members in the human genome [13].
Further analysis of these mobile elements with respect to these points remains to be performed.
In all, 1,951 mobile elements with a total length of 1,468,873 bp were predicted (Table 2).
Retrotransposons are mobile elements with the property of moving within a gene via a copy and paste mechanism.
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The acquisition of a mobile element with a CRISPR might pose a serious danger to the host if the CRISPR contains spacers matching the chromosome.
Since there are no known transposable elements that encode a transposase intermediate between the transib transpose and RAG-1 with respect to the amino terminus section of RAG-1, this would imply that another intermediate form of mobile element with an amino terminus similar to RAG-1 preceded the insertion of the RAG-1 precursor gene adjacent to the RAG-2 gene.
The association of mobile element with the complete luxIR-type quorum sensing system has been previously reported.
Taken together, these observations suggest recent horizontal acquisition and dissemination of vcrABC across all Dehalococcoides ecotypes by way of a ssrA-specific mobile element with conserved attachment site and integration module.
For example, epigenetic DNA methylation is associated with the silencing of selfish mobile elements and with the imprinting of alleles inherited from a particular parent.
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