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These host defenses impart selective pressure on phages and mobile elements to evolve countermeasures against CRISPR immunity.
As older Internet companies seek more ways to add social and mobile elements to their offerings, buying start-ups will continue to make more sense.
This detailed map of constraint suggests that mammalian genomes co-opt fragments of mobile elements to act as gene regulatory sequence on a large scale.
Doubling the whole genome, distributing copies of mobile elements to different sites, and incorporating similar domains in different proteins provide the necessary raw materials for generating complex interactive networks in cells.
Another major benefit from these genomes includes the ability to develop molecular markers based on GAS mobile elements to tag and track field-level diversity of the circulating strains; this will be of paramount significance in vaccine development and testing.
This may reflect the genetic flexibility endogenous in the mobile elements to generate novel functional/structural variants.
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"I can't see a single campaign going forward that doesn't have a mobile element to it, from the lowliest act to the biggest global superstar," she said.
"Inserts in CD packaging, radio & TV advertisements – all of your traditional marketing channels – now have a mobile element to them.
When present, they are used to optimize the placement of junction breakpoints with respect to mobile elements and to output additional information about the molecular effects of mutations on specific genes.
Also, enrichment in mobile elements seems to be linked to genome plasticity in some facultative symbionts (Gillespie et al. 2012).
Mobile elements seem to contribute equally to orphan gene formation in ants and in Arabidopsis, but are significantly more frequently found in primates.
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