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Briefly, cases have BP readings ≥150/100 mmHg based on one reading or ≥145/95 mmHg based on the mean of three readings and there is extensive phenotyping information from all individuals, including anthropometric data, plasma and urinary electrolytes, and diagnosis BP recordings.
Cases originated from severely hypertensive families (1700 sib-pairs and 800 nuclear families) and were defined as patients under antihypertensive treatment and with BP readings ≥150/100 mmHg based on one reading or ≥145/95 mmHg based on the mean of three readings.
For this study we defined cases (n = 596) as individuals with either blood pressure readings ≥160/100 mmHg based on the median of several measurements or under antihypertensive therapy.
The estimated pressure in the sagittal sinus was 7.9 mmHg based on the sinus area and the volume of flow.
9 Systemic hypertension was defined as systolic pressure ≥140 mmHg and/or diastolic pressure ≥90 mmHg, based on more than three measurements or current use of antihypertensive drugs.
Briefly, cases originated from severely hypertensive families (1700 sib-pairs and 800 families collected for transmission disequilibrium test) were defined as patients under antihypertensive treatment and with BP readings ≥150/100 mmHg based on one reading or ≥145/95 mmHg based on the mean of three readings.
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Fourth, we defined hypocapnia and hypercapnia as PaCO2 ≤ 30 mmHg and PaCO2 ≥ 50 mmHg, respectively, based on PaCO2 levels from previously published studies [5, 6, 23].
Fourth, we defined hypocapnia and hypercapnia as PaCO2 ≤ 30 mmHg and PaCO2 ≥ 50 mmHg, respectively, based on PaCO2 levels from previously published studies [ 5, 6, 23].
For the purposes of additional analyses, we divided the cohort by initial PaCO2 after initiation of post-ROSC ventilator settings into hypocapnia, normocapnia, and hypercapnia (defined as PaCO2 ≤ 30, 31 to 49, and ≥ 50 mmHg, respectively, based on previously published cutoffs in studies of traumatic brain injury and post-cardiac arrest) [5, 6, 23].
The choice to use the TAC device with an IAP of 12 mmHg was based on work performed by Malbrain and colleagues in 2006 [ 1].
17 The goal of a BP <140/90 mmHg has been subjected to extensive review by the Eighth Joint National Committee (JNC 8), and their recommendations on BP goals of <140/90 mmHg were based on expert opinion.
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