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Thus, future therapeutic approaches for MM should consider targeting pathways cooperatively regulated by both tumor suppressor genes.
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The clinician should consider a diagnosis of MM when myopathy is accompanied by clinical features of multi-organ dysfunction, which are summarized in Figure 1.
Evidence suggests (with one exception) that any segment of the oesophagus containing air with a diameter of >10 mm should be considered abnormal (Fig. 3a).
Some studies suggested that 2 mm should be considered the threshold for identifying mucosal thickening [20], and thus the prevalence of slight mucosal thickening may have been underestimated.
In the light of the last recommendations, after a long course of neoadjuvant treatment, all nodes with a short axis <5 mm should be considered benign, while morphological criteria should be used for short diameter ≥5 mm nodes [3].
The limits of the use of computer-guided piezocision are set by the maximum deviation observed; thus a safety distance of 1.5 mm should be considered, which confirms that this innovative technique is clinically applicable.
Part-solid nodules, especially those in which the solid component is larger than 5 mm, should be considered malignant until proven otherwise, provided either growth or no change is seen at the 3-month LDCT follow-up.
The exception to this rule is the portion of the oesophagus between the cardiac ventricles and the lower oesophageal sphincter; in this segment, dilatation >15 mm should be considered abnormal [9].
The IMWG consensus statement now recommends that SMM patients with more than one unequivocal focal lesion (diameter > 5 mm) should be considered to have symptomatic myeloma that requires treatment.
The baseline drift of up to ±6 mm should be considered for treatment planning.
A recently published study with autologous colon tumour vaccines has shown that DTH-reactions with a diameter exceeding 10 mm should be considered to reflect successful vaccination therapy and predict relatively good survival rates (Harris et al, 2000).
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