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As part of the phase II trial of AZD6244 in relapsed/refractory MM, extensive molecular profiling of a subset of patients was conducted to correlate the genetic characteristics of MM with clinical outcomes.
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Foci were relatively extensive, measuring 2.0 3.0 mm wide and up to about 4.0 mm AP.
Because P. falcipes is a small-size species (<20 mm) with extensive coloration and morphological variation, we suspected that it might represent a complex of cryptic species.
Affected lymph nodes were enlarged and had areas of necrosis and calcification varying from 1 mm to extensive throughout the entire lymph node.
This result is consistent with the report of Demain ([1986]), who showed that phosphate in the range of 0.3-300 mM generally supports extensive cell growth, whereas concentrations of 10 mM and above suppress the biosynthesis of many secondary metabolites.
The teeth with clinical crowns shorter than 2 mm or with extensive carious lesion and third molars were not included.
Biochemical markers of the bone remodeling represent an important tool to check the alterations in the bone turnover that occurs in MM patients with extensive bone disease.
Nasal mucosa and lacrimal bone were removed, and the ostium was increased in size to >8 mm diameter by extensive removal of bony fragments.
In a post-hoc analysis, ROC curves for the total OHIP-Sp score and more severe clinical attachment level outcomes (CAL ≥ 4, and CAL ≥ 5 mm); and more extensive tooth loss outcomes (≥ 2, ≥ 3, and ≥ 4 teeth) were used to assess whether OHIP-Sp shigherigher discriminative validity with more severe and extensive dental outcomes.
MM-PBSA requires extensive sampling of configurational spaces.
After one reaction sequence of pyrolusite with 3 mM aqueous Fe(II) extensive rod-like surface precipitates (b) cover the surface of every particle that was imaged.
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