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The mean E6/C10 skin test response increased in the BCG vaccinated group during the remainder of the experiment from a mean of 5 mm at week four, reaching a mean of 14 mm at week 52 (figure 1B).

In the pretreatment period, the mean pruritus VAS was 75.2 mm, significantly decreasing to 50.9 mm at week 2, 33.6 mm at week 24, and 31 mm at week 52, suggesting the prolonged efficiency on pruritus.

67 This reduction is remarkably larger than that by nalfurafine (41.6 mm at week 24 and 44 mm at week 52).

The effect was associated with a significant increase in pre-dialysis base excess during the citrate study period (2.4 ±0.5 mM at week 6 vs. 1.0 ±0.4 mM at week 0, p = 0.03).

Based on the study protocol, nail growth <5 mm at Week 48 was considered a therapeutic failure (i.e., not a Clinical Success).

During the citrate dialysis fluid period the intra-dialytic base excess shift was significantly reduced (+3.9 ±0.5 mM at week 6 vs. +5.6 ±0.5 mM at week 0, p = 0.006) and after 6 weeks it was significantly lower compared to control (+3.9 ±0.5 vs. +5.0 ±0.5 mM, p = 0.02), Figure  2B.

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Similar(53)

Total wrinkle area decreased in a time-dependent manner after treatment with bee-venom serum from 26.04±3.46 mm at baseline to 25.75±3.31 mm, 24.84±3.61 mm, and 24.44±2.69 mm at weeks 4, 8, and 12, respectively.

There was one case (2%) of steroid-related raised IOP at 1 month (19 mm Hg at week 1 to 30 mm Hg at month 1), which returned to baseline upon cessation of steroid.

Among the 73 patients (24.7%) with POAG/OHT and a baseline IOP >21 mm Hg, mean ± SD IOP at baseline was 25.7 ± 5.0 mm Hg, which decreased to 16.4 ± 4.0 mm Hg at week 6 (34.5% reduction) and 16.7 ± 3.9 mm Hg at week 12 (32.0% reduction) following bimatoprost treatment (both P < 0.0001 vs baseline).

Following initiation of bimatoprost 0.01% therapy, IOP decreased to a mean of 14.1 ± 3.3 mm Hg at week 6 and 14.5 ± 3.4 mm Hg at week 12, which were statistically significant reductions from baseline (both P < 0.0001).

The upper limit of the 95% CI of the between-group difference did not exceed 0.14 mm Hg at week 12 and was well within the 1.5 mm Hg non-inferiority margin at each hour.

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