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Sterile water for injection (250 mL bags) was purchased from B. Braun (Melsungen, Germany).
When she stopped pumping and switched to a special formula designed for babies with allergies, at 5 months, she had managed to store an astonishing 60,180 ml bags of frozen breast milk, allowing for a gradual transition to formula.
The proposed lipid emulsion with the vitamins are available in 2 volumes: 50 ml opaque syringes and 150 ml bags.
AMD473 was supplied as a sterile 0.4 mg ml−1 solution in 0.9% saline, as 200 mg (500 ml) bags or 10 mg (25 ml) ampoules, by the Cancer Research UK Formulation Unit, Department of Pharmaceutical Sciences, University of Strathclyde.
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Nevertheless, it is recommended that an injection of adrenaline is ready and available in case it is needed to treat a severe anaphylactic reaction, and also that the antivenom from the vial is administered diluted in a 100 ml bag of intravenous solution for infusion over 30 minutes.
Dipeptiven® (Fresenius-Kabi, Carnaxide, Portugal) (50 ml/1250 ml bag) was included in both regimens.
Study material or placebo was administered in a 100 mL bag of normal saline.
Once randomised, the pharmacy will independently prepare the treatment solution (ropivacaine or normal saline (NS)) in a standardised 100 mL bag.
Also the supplies required to administer TXA (e.g. 10 mL syringe, 100 ml bag of saline, large gauge needle) are likely to be available and affordable even in limited resource setting.
Each vial was reconstituted with water for injection to give a solution equivalent to 4 mg ml−1 XR5944.14 and the required dose was then added to a 250-ml (later 500 ml) bag of 5% glucose injection BP, which was stored for up to 4 h at 2 8°C before use.
A third party not involved in the conduction (KAZ, Kantonsapotheke, Zurich) performed randomization and prepared the study solution, either balanced 6% HES 130/0.4 or lactated Ringer's solution, by sealing the identical 500-mL bags in black plastic foil concealing the product label and content.
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