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Recently, the NIEHS has embarked upon an effort to coordinate mixtures research across both intramural and extramural divisions in order to maximize mixtures research results.
It is one of the future challenges for mixtures research to combine information from both approaches.
The future of mixtures research at NIEHS will include projects from nominations to DNTP, studies by extramural investigators, and collaborations across government agencies that address high-priority questions in the field of mixtures research.
However, the mixtures research effort at NIEHS, to date, has been driven by test article nominations to the DNTP or by investigator-initiated research through DERT.
A path forward for NIEHS mixtures research will be based on feedback from a Request for Information (RFI) designed to gather up-to-date views on the knowledge gaps and roadblocks to evaluating mixtures and performing cumulative risk assessment, and a workshop organized to bring together mixtures experts from risk assessment, exposure science, biology, epidemiology, and statistics.
Perhaps, the most significant influence on conducting chemical mixtures research is the passage of laws requiring the EPA to investigate the potential toxicity of various mixtures, specifically the Comprehensive Environmental Response, Compensation, and Liability Act of 1980, the Food Quality Protection Act of 1996, and the Safe Drinking Water Act Amendments of 1996.
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According to Hubbard, casting is a mixture of research and sixth sense, and nothing compares to a face-to-face meeting.
But finding the right enhancement technique to drive the drug through the skin is a mixture of research plus trial and error.
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