Sentence examples for mixtures of mutations from inspiring English sources

While they resolved some of the previous limitations from TP53 studies (mostly by examining large portions of the human genome which are usually not under selection and which have a nucleotide context that is representative of the whole human genome) they still did not address the important issue of examining mixtures of mutations generated by different mutational processes.

In order to solve the question whether the detected mixture of mutations consisted of different single, double or multiple HCMV mutants, UL97 amplicons were cloned into E.coli and individual clones were further analyzed.

Single-base extension (SBE) reaction products using a mixture of mutation site-specific probes were then spotted onto a 384-format SpectroCHIP II with the MassARRAY Nanodispenser.

This suggests a picture of neoplasia in which all neoplasms have a mixture of mutation types point mutations, deletions, fusion genes, etc. Rather than leukaemias being driven by fusion genes while carcinomas were driven by point mutations and deletions, the main difference between carcinomas and leukaemias may simply be that carcinomas have more mutations than leukaemias.

MtDNA is purely maternally inherited and since it is present in multiple copies, patients can either have all mutated mtDNA (homoplasmic mutations) or a mixture of mutated and wild-type mtDNA (heteroplasmic mutations).

To confirm this inference, we determined the correlation between HBx protein and HIF-1 α expression in HCC tissues, in which HBx mutants occurred with the mixture of these mutations.

Many of these mutations are heteroplasmic, with a mixture of mutated and wild-type mtDNA present in varying proportions within cells of the same individual.

Direct sequencing seems unable to provide satisfactory results for detection of EGFR mutations in samples containing a mixture of mutated and wild-type DNA.

Pathways in HER2+ are a mixture of TP53 (mutation rate 72%) related pathways and PIK3CA (mutation rate 40%) related pathways.

To confirm the sensitivity of the MASA method, PCR was performed in the mixture of diluted mutation-positive DNA with wild-type DNA.

In addition to the hot spot mutation, the mixtures induce complex mutations, which consist of a small deletion and a base substitution.