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In both cases, the arrival of agriculture from southwest Asia after 9,000 years ago catalyzed profound population mixtures of groups related to Southwest Asian farmers and local hunter-gatherers.
There was no change in C O O C bending vibrations in physical and freeze-dried mixtures of group-3.
Both physical and freeze-dried mixtures of group-1 showed decreased melting peak temperature and increased enthalpy change.
Physical and freeze-dried mixtures of group-2 of ARTM showed decreased k values 0.22 h−1 and 0.18 h−1, respectively.
C H bending vibrations of physical and freeze-dried mixtures of group-3 were red shifted at 1466.13 cm−1 and 1466.11 cm−1, respectively– 3 j)).
Physical and freeze-dried mixtures of group-1 showed characteristic bands of C H stretching vibrations in functional group region at 2882.76 cm−1 and 2883.43 cm−1 which was single broader peak instead of four peaks of ARTM alone; in the fingerprint region, C O O C bending vibrations of both physical and freeze-dried mixtures of group-1 were unaltered.
C O C stretching vibrations of physical mixtures of group-1 were red shifted at 1033.31 cm−1 and 1278.83 cm−1, while its freeze-dried mixtures were also red shifted at 1060.12 cm−1 and 1279.05 cm−1, respectively.
C O C stretching vibrations of physical mixtures of group-3 were also red shifted at 1060 cm−1 and 1278.90 cm−1, whereas its freeze-dried mixture was red shifted at 1060.25 cm−1 and 1279.04 cm−1, respectively.
C H bending vibrations of physical mixtures of group-1 were red shifted at 1456.79 cm−1 and 1465.91 cm−1, while its freeze-dried mixtures were red shifted at 1456.91 cm−1 and 1465.74 cm−1, respectively.
Scanning electron microscopic photographs of artemether (ARTM) alone showed typical crystalline blocks of ARTM, while in group-1 SDs of ARTM, SEM showed that these crystalline structures of ARTM were decreased in size enormously having no sharp edges in both physical and freeze-dried mixtures of group-1.
The principal ARTM peak of ARTM and PEG6000 in physical and freeze-dried mixtures of group-2 were present but having lower intensity compared to pure ARTM and this decrease of intensity were more pronounced in freeze-dried mixture than in physical mixture and 2(F)), as also seen for rofecoxib [ 12].
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