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Overall, the results showed that increases in pH, hardness and DOC concentration led to decreased mixture toxicity of Cu II) and Cr VI) by reducing the concentrations of toxic species such as Cu2+ and HCrO−4.
Therefore, the mixture toxicity of the antibiotics can better reflect their environmental risks.
Whether the CA and IA can predict mixture toxicity of phenolic compounds with similar and dissimilar action mechanisms was studied.
Therefore, it can be concluded that both CA and IA can predict reliable results for the mixture toxicity of the phenolic compounds with similar and dissimilar action mechanisms.
Moreover, the mixture toxicity of four selected pharmaceuticals (diclofenac, ibuprofen, metoprolol and propranolol) was evaluated in binary mixtures using full factorial experimental design.
The predictive toxicities are in good agreement with the experimental toxicities, which testifies to the predictability of the mixture toxicity of the NBDs.
Similar(47)
Two different concepts, termed concentration addition (CA) and independent action (IA), describe general relationships between the effects of single substances and their corresponding mixtures allowing calculation of an expected mixture toxicity on the basis of known toxicities of the mixture components.
The IA concept was able to predict accurately mixture toxicities of dissimilarly acting chemicals for lethal responses, whereas the CA concept did so in three out of four pairings for feeding response, irrespective of the chemical mode of action.
The predictions of mixture toxicity for chemicals are commonly based on two models: concentration addition (CA) and independent action (IA).
As a result, the illustration has focused on organizing of the exposures into the four Groups and identifying which chemicals are the drivers of mixture toxicity for Group IIIB.
In contrast, the concept of concentration addition provides highly accurate predictions of s-triazine mixture toxicity, irrespective of the effect level under consideration and the concentration ratio of the mixture components.
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