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In vitro toxicity assays, using human or other mammalian cell lines, provide information on hazards relevant for human toxicity and can detect the sum effect of the whole mixture of toxicants present.
We designed the present research to investigate the importance of tissue repair in the final acute hepatotoxic outcome upon exposures to mixture of toxicants comprising thioacetamide (TA), allyl alcohol (AA), chloroform (CHCl3) and trichloroethylene (TCE).
Smolts released into the river or river mouth area must pass through an industrialized urban area that likely contains a mixture of toxicants, which might be compromising fish health and increasing their susceptibility to disease [35], [36].
The smoke contains a mixture of toxicants including carbon monoxide and metals.
Jonker et al. (1993) also examined a mixture of toxicants that act by differing mechanisms but affect the same target organ.
The destruction and combustion of the WTC towers released a complex mixture of toxicants into the New York City environment on and after 11 September 2001 (Lioy et al. 2002; McGee et al. 2003; Offenberg et al. 2003).
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Studying mixtures of toxicants yields a more accurate picture of how contaminants work in the environment.
Thus, the use of throughput genomic approaches after long-term exposure to mixtures of toxicants might help in the assessment of interactions such as additivity, synergism, or antagonism.
Nevertheless, these strains may have added value above that of existing techniques in the detection of mixtures of toxicants and in early warning systems.
Finally, we believe that transcription profiling will enable mechanistic insight in responses to mixtures of toxicants, a relatively new and unknown field in (eco toxicology.
Exposures in the real world do not occur to single substances but to mixtures of toxicants that can interact with each other or affect different steps of multistage disease processes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com