Suggestions(2)
Exact(4)
However, instead of the expected product (Z)- 8a, a mixture of protected capreomycidine (rac)- 14 and epicapreomycidine (rac)- 15 (diastereomeric ratio (d.r).r
A solution of a mixture of protected capreomycidine (rac)- 14 and epicapreomycidine (rac)- 15 (580 mg, 1.77 mmol) in aqueous HCl (6 M, 10 mL, 60 mmol) was stirred at rt for 4 h.
Thus, formation of the respective arginine derivative and domino-type ring closure provided a mixture of protected capreomycidine (rac)- 23 and epicapreomycidine (rac)- 24 (d.r.~1 : 1) in 62 % yield over two steps.
Intermediate 16 was then used in the domino reaction to give a mixture of protected capreomycidine (rac)- 17 and epicapreomycidine (rac)- 18 (d.r.~1.8 : 1.0) in 49 % yield over two steps from (Z)- 11d.
Similar(55)
This resulted in a mixture of the protected and the free amine which was treated once again with di- tert-butyl dicarbonate under conditions that would also cleave the pivaloyl ester.
Attempts to dive deep or to sojourn underwater began long ago, but in man's efforts to emulate fish two very tough problems have always plagued designers of equipment: providing a supply of breathable air or a suitable artificial mixture of gases and protecting a diver from the immense pressure created by the weight of the water above him.
A mixture of the four protected mice against the 12 strains responsible for the majority of GBS disease in humans.
A mixture of the crude protected acyclic peptide (1 equiv, 90 μmol, 100 mg), NaHCO3 (5 equiv, 450 μmol, 36 mg), DMF (100 mL), and DPPA (3 equiv, 270 μmol, 80 mg) was stirred overnight.
For most investors, the message is to hold tight and tweak their portfolios so that they hold a mixture of assets to protect their money.
Attempts to dive deep or to sojourn underwater began long ago, but in man's efforts to emulate fish two very tough problems have always plagued designers of equipment: providing a supply of breathable air — or a suitable artificial mixture of gases — and protecting a diver from the immense pressure created by the weight of the water above him.
A 500 μL aliquot of the bacterial suspension was added and the final mixture protected from light [ 21].
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