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Aroclor 1254 is a commercial mixture of polychlorinated biphenyls (PCBs), which is defined as being 54% chlorine by weight.
Aroclor 1254 is a well-known hepatotoxin, consisting of a complex mixture of polychlorinated biphenyls (PCBs) and thus may being a potent topoisomerase IIα poison as well [ 19].
Aroclor 1242, a mixture of polychlorinated biphenyls (PCBs), activates neutrophils to produce superoxide anion (O2-) by a mechanism that involves phospholipase C-dependent hydrolysis of membrane phosphoinositides; however, subsequent signal transduction mechanisms are unknown.
Aroclor 1254 is a well-known hepatotoxin and consists of a complex mixture of polychlorinated biphenyls (PCBs), some of which have the ability to activate the aryl hydrocarbon receptor (AhR) and other transcription factors (TFs).
In January 1999, a mixture of polychlorinated biphenyls (PCBs) and dioxins was unintentionally mixed with recycled fats used for animal feeds in poultry, swine, and cattle farms in Belgium resulting in a drop in egg production, a reduction in egg hatchability, and an increased mortality of chicks [ 24, 25].
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Desaulniers et al. (2003) found that use of 2,3,7,8-tetra-chlorodibenzo 2,3,7,8-tetra-chlorodibenzo 2,3,7,8-tetra-chlorodibenzove effects of a mixture of coplanar polychlorinated biphenyls (PCBs), polychlorinated dibenzo- p-dioxins, and polychlorinaTCDDdibenzofurans on circulatoxicthyroxinequivalentsentrations in neonatal rats.
Just as we expressed the total effect of the joint exposure (A,B) in terms of an isoeffective dose of B given by γ A + B, the TEF method allows toxicologists to express a mixture of similarly acting polychlorinated dioxins, polychlorinated dibenzofurans, and polychlorinated biphenyls by a single equipotent dose.
Human milk samples were collected and analysed for the levels of polychlorinated dibenzodioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and selected dioxin-like polychlorinated biphenyls (PCBs).
Male Sprague-Dawley rats were daily given orally for 22 days a regimen consisting of polychlorinated biphenyls (PCBs), 1 mg/day; polychlorinated quaterphenyls (PCQs), 1 mg/day; polychlorinated dibenzofurans (PCDFs), 10 micrograms/day; or a mixture of PCBs, PCQs and PCDFs (Mix-1, 1 mg + 1 mg + 10 micrograms/day).
When determining the long-term effects on an animal of polychlorinated biphenyls, some species are easy to evaluate.
The contamination consists of tons of polychlorinated biphenyls, or PCB's, chemicals that were dumped from two General Electric factories 200 miles upriver from Manhattan until 1977.
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