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Breast cancer bone metastases present with a mixture of phenotypes ranging from osteoblastic to osteolytic lesions.
Are they "bold and intrepid explorers," the "wretched refuse" of the larger population, or perhaps a diverse mixture of phenotypes?
The npr1 alleles produced a mixture of phenotypes in RIM, and out of the 43 alleles tested, 11 had a significant RIM (RIM+, Figure 1a), meaning that the growth of Pto in MeJA treated plants was significantly lower than in mock treated plants (Student's test of one tail, with P<0.05).
The tree topology suggests that this progenitor of population 4 might have been related to the modern populations 6 and/or 7. Population 5 forms a separate cluster in the neighbour-joining tree, but has a mixture of phenotypes, including two- and six-row barleys, hulled and naked forms, spring and winter habits and both daylight responsive and nonresponsive.
Bull et al. (2002) reported that TCE-induced liver tumors in mice have phenotypic characteristics of both DCA- and TCA-induced tumors (i.e., a mixture of phenotypes with some tumors c- jun positive, some tumors c- jun negative, and some tumors displaying both).
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3 5 Moreover, the current ICD-10 classification of gastritis is not organised according to aetiology but is merely a mixture of phenotype and aetiology and also includes duodenitis (box 1).
Each of these plasmids can be lost stochastically during cell division, leading to a mixture of possible phenotypes.
Fish injected with 3 ng of MO2 also had a mixture of different phenotypes with 40% of injected fish exhibiting developmental abnormalities, 20% appearing normal and 40% of them dead.
The mixture of morphological phenotypes in Bowmans' capsule, along with multipotency of CD24+CD133+ PECs, are suggestive that the PEC population is comprised of several cell types with various roles, some of which might serve to replace podocytes.
This indicates that the basal and the hyperrepressed level of csgB reflects a mixture of cellular phenotypes where the fraction of curli-on cells is significantly lower as compared to the wild type, or it becomes undetectable.
Again, the likeliest explanation is the mixture of effector phenotypes present in this population, not all of which may be disease-relevant, and the possibility that effector Th cell recruitment to inflammatory sites is partially redundant.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com