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The differing electron densities observed in F86YF87Y structure suggest the presence of a mixture of ligands with different head groups.
A promising advantage of MNT is the interchangeable nature of the modules, offering the exciting prospect of generating an MNT or an MNT cocktail that possesses the best ligand, or mixture of ligands, and intracellular localizing signals that are tailored to the molecular profile of an individual patient's tumor.
By panning against an immobilised ligand, or a mixture of ligands, the gene encoding the corresponding receptin can be identified.
In the glycans in which GalNAc is the nonreducing terminal residue, there is an approximately equal mixture of ligands with α- and β-linked GalNAc.
28 Anions have also been shown to direct the observed distribution within a family of metal complexes composed of a mixture of ligands, with examples including both terpyridine 29 and bipyridine 30, 31 systems.
In this paper, a recently developed analytical methodology for the bioaffinity profiling of mixtures of compounds targeting the histamine receptor was transferred, optimized, and applied for bioaffinity assessment of mixture of ligands targeting the CXCR3 receptor.
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A beautiful example is the classic experiment by Lehn and co-workers 5 in which a mixture of ligand strands containing two to five 2,2′-bipyridine groups spontaneously self-sort into linear double helicates, each containing two ligands with equal numbers of binding sites, in the presence of CuI ions.
& Marquis-Rigault, A. Self-recognition in helicate self-assembly: spontaneous formation of helical metal complexes from mixtures of ligands and metal ions.
The first group of Janus nanoparticles is those obtained via self-assembly, of, e.g., block copolymers, and mixtures of ligands that in some cases show competitive adsorption on the surfaces of the nanoparticles.
Similarly, panning against complex mixtures of ligands has a tendency to select for certain interactions.
One attractive application is panning against complex mixtures of ligands, e.g. mammalian serum coated onto wells.
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