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Even the excitation of trigeminal brainstem neurons by the application in the meningeal subarachnoid space of a mixture of inflammatory mediators was subjected to tachyphylaxis [72]. .
This idea is clearly supported by animal experiments in which application of a mixture of inflammatory mediators to the dura mater leads to peripheral and central trigeminovascular sensitization [25, 131].
Such medium is considered to contain a physiologically relevant mixture of inflammatory mediators (Table 1).
At the site of injury, a mixture of inflammatory substances is released and amplifies the nociceptive input by activating dormant neurons and increasing peripheral excitability [ 24].
A partial/complete reconstitution of the mixture of inflammatory and mesenchymal cells in the synovial tissue is also possible by adding some or all of the adherent and non-adherent cells obtained during the isolation procedure of SFB [ 15].
By an unknown mechanism, following transection, the two stumps are rejoined by a poorly characterized structure known as "the bridge" that can be several millimeters in length and is composed of a mixture of inflammatory cells and matrix (Jurecka et al., 1975) and thus seemingly a hostile and non-directional environment for axonal regrowth.
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Cytologic smears showed a mixture of mature inflammatory cells.
Cytologic smears showed a mixture of mature inflammatory cells, and polyclonality was found on IgH gene rearrangement testing.
Histology and immunohistochemistry demonstrated a mixture of abundant inflammatory cells, including lymphocytes, histiocytes, plasma cells, and occasional eosinophils, among a stromal matrix composed of glial elements and condensed vitreous, but no retinal pigment epithelium (RPE) was present.
At the time of surgery, it was also noted that the patient had a significant ERM which was removed and histologically consisted of a mixture of abundant inflammatory cells, in addition to glia and condensed vitreous, without cells from the RPE (Figs. 4, 5, and 6), as in the previous case.
However, breast tumour tissues are a mixture of stromal, inflammatory and malignant cells, and genetic lesions usually affect only a subgroup of tumour cells.
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