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The QCM sensors (A, B and C) gave a good linearity against different sample concentrations of the 2,3,7,8-tetrachlorinated 2,3,7,8-tetrachlorinatedand a mixture of dioxins.
Relationship between tT4 and exposure to a mixture of dioxins, furans, and PCBs in rats was shown to be additive at the lowest doses, but synergism was observed at higher doses (Crofton et al. 2005).
The high toxicity of a few dioxin congeners, the availability of a scheme to characterize the toxicity of a mixture of dioxins and related compounds and the long half-life of these compounds facilitated epidemiological research.
Seventy-five dioxin congeners and 135 furan congeners comprise the complex mixture of dioxins, of which 7 and 10 congeners, respectively, are capable of binding to and activating the aryl hydrocarbon receptor (AhR) (Van den Berg et al. 2006).
The main objective of the present study was to test the hypothesis that the increased tumor incidence observed with a mixture of dioxins could be predicted based upon the potency-adjusted dose-additive effect of the individual compounds present within the defined mixture.
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It is a persistent environmental contaminant usually present in a complex mixture of dioxin-like compounds, and is a carcinogen.
AhR-mediated transcriptional activity of cleaned plasma extracts was interpolated onto the TCDD dose-response curve of AhR mediated luciferase activity and expressed as TCDD equivalents (AhR-TEQ), which represents the total TCDD-toxic potency of a mixture of dioxin-like compounds.
The TEF approach is the most commonly used method of assessing the risk of complex mixtures of dioxins and DLCs.
Complex mixtures of dioxins [hereafter "dioxin" refers to dioxin-like compounds (DLCs) as defined below] also elicit a variety of noncancer effects.
The U.S. Environmental Protection Agency EPAA) has classified TCDD as "carcinogenic to humans," and the agency has characterized complex mixtures of dioxins as likely human carcinogens (U.S. EPA 2002).
This predictive approach, and various conceptually similar ones, have now found wide applicability to the risk assessment process associated with exposure to complex mixtures of dioxins, dibenzofurans, and related compounds.
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