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This Asn has been shown to drive assembly of the monomeric peptide in a membrane environment to a mixture of dimers and trimers.
The mixture of dimers was purified by affinity chromatography using a 25 mL TALON Superflow metal affinity resin column.
The softer repulsion (shallow, repulsive force at D < DC) is also attributed to the mixture of dimers and tetramers.
AP-1 refers to a mixture of dimers formed between members of the Jun, Fos, and ATF families.
Previous analytical ultracentrifugation studies of His-ZapA performed by Small et al. (25) were compatible with E. coli ZapA being an equilibrium mixture of dimers and tetramers.
Interestingly, titration experiments of the p73 OD known to exist as a mixture of dimers and tetramers (Coutandin et al., 2009) with the p63 TID peptide resulted in the disappearance of all peaks by the formation of soluble aggregates.
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Strikingly, single Arg740 and Arg761 residue mutations in interfaces B and D of BASS cause potent defects in specifying BASS tetramers producing a mixture of dimer and tetramer species.
Fraction 1 contained monomeric DdP2XA and other impurities, fraction 2 contained a mixture of dimer and trimer, fraction 3 contained pure trimers, and fractions 4 6 contained high molecular mass impurities.
IDE exists as a mixture of monomers, dimers, and tetramers with the dimer the predominant species [11].
IDE is known to exist as an equilibrium mixture of monomers, dimers, and higher oligomers, with the dimer being the predominant form.
The second transition occurred at higher SDS concentrations (∼10 mM), where neuronal UCP dimers were further dissociated into a mixture of loose dimers and monomers.
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