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The authors rightfully say "We do not know how trans-SNARE interactions lead to this dequenching, but it is not symmetric, as expected for true lipid mixing, and is not proportionate to the content mixing for each reaction condition; thus, it cannot be relied on as a faithful reporter of fusion".
The convergence property of the RJMCMC sampler for the partially observed case is shown in Figure 3. Compared with the fully observed case, the autocorrelation length in the partially observed case is typically longer, but the RJMCMC sampler can still induce good mixing for each dataset with adequately large sample size.
The authors rightfully say "We do not know how trans-SNARE interactions lead to this dequenching, but it is not symmetric, as expected for true lipid mixing, and is not proportionate to the content mixing for each reaction condition; thus, it cannot be relied on as a faithful reporter of fusion".. What is the origin of the asymmetric lipid dye transfer?
We do not know how trans-SNARE interactions lead to this dequenching, but it is not symmetric, as expected for true lipid mixing, and is not proportionate to the content mixing for each reaction condition; thus, it cannot be relied on as a faithful reporter of fusion.
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