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The mixed treatment group experienced more significant alterations, favoring an increase in red pulp and in the structure and size of the follicles.
Considering the dose-dependent nature of the effects of L. plantarum ZJ316, this may be the reason why mixed treatment group (Group 5, 105 g mequindox and 1 × 10 L. plantarum ZJ316 CFU/d) experienced a better probiotic effect than the same dose of antibiotic and probiotic administered alone (Group 1 and Group 4).
Loss of MSMB mRNA expression was however associated with early biochemical relapse in PADT treated men and is consistent with one older study has also previously shown that loss of expression was a predictor of a poor outcome in a mixed treatment group including men treated by primary androgen deprivation [ 31].
During treatment boys and girls can be placed in boys-only, girls-only and sex-mixed treatment groups.
Studies investigating the differences between mixed-sex and single-sex, mostly women-only, reported differences between women in single-sex and mixed-sex treatment groups, in that women in single-sex programs showed more individual problems with drugs and alcohol (Greenfield et al. 2008).
For boys, we did not expect these differences between single-sex and mixed-sex treatment groups.
Concerning the placement of adolescents in single-sex or mixed-sex treatment groups, the institutions made this determination.
The influence of group composition in terms of girls-only, boys-only and mixed-sex treatment groups on treatment outcomes has rarely been studied.
For the variable internalizing problems (anxiety/depression), self-reported offending, and official offending findings suggest significant effects between single-sex and mixed-sex treatment groups.
Thus, at the time of sampling, the mixed-strain treatment groups A and B each consisted of two replicates (total n = 4).
Moreover, our study adds to our understanding of the impact of placing boys and girls in single-sex versus mixed-sex treatment groups on individual development and functioning.
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