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For the obligatory model, h was set to zero, whereas for the mixed transport model, the relative mobility of the unbound transporter parameter (h) was chosen to be 0.04, based on a previous report that estimated an upper confidence interval of 4% for efflux by facilitated transport relative to obligatory exchange (15).
The computational model could only account for experimental [C] l-serine uptake data when the transporter was not exclusively in exchange mode, best described by the mixed transport model.
In contrast, in the case of the mixed transport model, [C] l-serine influx would eventually reach an equilibrium concentration that would be identical across all experimental conditions.
The overshoot curve was interpreted to represent [C] l-serine uptake by an exchange mechanism coupled with a facilitated transport mechanism (as predicted by the mixed transport model).
Thus, the carrier model was hypothesized to represent a single transporter that permits substrate transport by either (1) obligate exchange or (2) nonobligate exchange with a facilitated transport component (mixed transport model).
The mixed transport model predicted that a high outwardly directed l-serine concentration gradient would elicit overshoot curve; this was not predicted to occur if exchange was fully obligatory.
Similar(48)
Transport model for mixed solvents in glassy polymer membrane is rare in literature.
We present a two-dimensional time-dependent semiclassical transport model for mixed-state scattering with thin quantum films.
The main research tool was a FLUENT-based novel mass transport model consisting of two modules, a 2D axisymmetric SST model and a mixed reactor model of the biological reactor (BR).
In this work, based on Liu et al.'s transport model for single solvent/polymer membrane system, a transport model for the absorption of mixed solvents in glassy polymer membrane is established.
The Timber Transport Model developed for the United States Department of Agriculture USDA Forest Servicece during the early 1970s (Sullivan, 1974) is an example of combining mixed integer linear programming with network programming.
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