Five tumours were composed of spindle cells, one of epithelioid cells and five were mixed spindle and epithelioid cells.
Seven tumours were composed of spindle cells and nine were mixed spindle and epithelioid cells.
Three tumours were composed of spindle cells and one was of mixed spindle and epithelioid cells.
Eleven of the tumours were composed of spindle cells and eight were of mixed spindle and epithelioid cells.
In a case series of 14 uveal melanomas, the SUVmean was significantly increased in mixed cell verses spindle cell tumours.
Histological examination of the mass revealed the characteristics of mixed spindle and epithelioid cell GIST, positive for c-Kit and negative for S-100 protein, glial fibrillary acidic protein (GFAP), desmin and CD34 (not shown).
Furthermore, SDH-deficient GISTs have distinctive clinicopathological features characteristic pathological, and clinical characteristics, including a predilection for young women, gastric localization, mixed epithelioid and spindle cell morphology, diffuse KIT and ANO1 (DOG1) IHC positivity, frequent lymph node metastases, and an indolent course of disease even when metastases are present 5, 6.
Based on their cell type 14 tumours were classified as epithelioid, 28 as mixed, and 33 as spindle cell type.
Early and later passages, as well as subclones with different morphologies (epithelial, spindle cell, mixed) were available.
Cases were classified according to the International Classification of Childhood Cancer (ICCC-3), third edition (Steliarova-Foucher et al, 2005) using the following histology codes: 8910/3, embryonal RMS; 8991/3, alveolar RMS; 8900/3, not otherwise specified; 8901/3, pleomorphic; 8902/3, mixed type; and 8912/3, spindle cell.
