Indeed, most of these studies involved, on one hand, mixed samples including relapse and new diagnoses of various classes of necrotizing vasculitis and, on the other hand, acute manifestations of the disease as well as chronic immunosuppressive-related infections [ 6, 7, 9, 18, 24].
Additionally, in case of mixed samples (including BSA and IgG at 1 μmol L−1 concentration, each), no longer a constant EM diameter was regarded as for FM, but a size range between 6 nm and 12 nm EM diameter was scanned to follow the separation of analytes (scan time at 18 s, time for detector reset between scans at 3 s).
Four studies reported on mixed samples, which included paediatricians, but only two of these analysed paediatricians as a separate subgroup (Table 1).
The psychometric properties of PIPS have been investigated in two studies by Wicksell et al. [ 8, 9]; the samples included participants with mixed pain conditions and a large sample with participants who had disorders associated with whiplash.
cHL samples included nodular sclerosis (n=47), mixed cellularity (n=18), lymphocyte rich (n=8) and lymphocyte depleted (n=3) cases.
The samples included 46 normal breast tissue samples from healthy women, 22 pure DCIS, 31 mixed DCIS-IBC and 186 IBC of stage I and II.
The samples included: 15 osteoblastic sarcoma, one fibroblastic, four small cell, three chondroblastic, two teleangetatic, one round cell, and one mixed cell sarcomas.
The BFS was developed to assess BF in breast cancer patients (Antoni et al, 2001), but the German version was validated on a mixed cancer sample including mainly CRC patients (Mohamed and Böhmer, 2004).
For S1, RNA was extracted from a mixed tissue sample (including leaves, stems, stolons and flowers) of above ground parts of a plant grown pot that was placed in darkness for 24 hrs prior to material collection.
Finally, the study was applied to determine the vitamins in several real aqueous samples including mixed juice fruit, urine and tap water samples and relatively good results were obtained.
