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9 Simple comparison analyses and mixed models analyses were applied.
The statistical analyses were Pearson correlations and Mixed Models analyses in SAS® software.
However, the non-parametric analyses gave largely the same results as the mixed models analyses.
This will be done by including a predictor-by-treatment group-by-time interaction term to the mixed models analyses.
Mixed models analyses were conducted to examine changes in distress and quality of life measures across the three time points.
To handle missing baseline measurements (and therefore increase power), the missing indicator method was used in linear mixed models analyses [ 29].
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The effects of treatments on tumour volume were assessed using mixed models analysing the tumour volume at D4, 8, 11, 15, and 18.
Metamorphic mass, larval period and growth rate were log-transformed to homogenize variances and analyzed with mixed model analyses of (co) variance using the MIXED procedure [ 47].
Mixed model analyses were performed with STATA software (release 13; StataCorp., College Station, Texas, USA).
In mixed model analyses, the Satterthwaite approximation was used to calculate the denominator degrees of freedom in the mixed models [52].
The effect of the morphology of froglets at Gosner stage 46 on jump length was analysed with mixed model analyses of variance (ANOVAs).
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