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Baseline pupil diameter did not vary significantly with circadian time (p = 0.668; mixed model univariate ANOVA).
The PIPR also showed significant variation between the individual participants (p<0.001; mixed model univariate ANOVA).
There was also a significant difference in the maximum pupil constriction (mm) between participants for both the 488 nm and 610 nm stimuli (p<0.001; mixed model univariate ANOVA).
The kinetics of the 488 nm PIPR redilation show significant variation with circadian time (p = 0.014; mixed model univariate ANOVA), similar to the PIPR amplitude data (Fig. 3A), with the slowest kinetics at 19 h.
The ipRGC controlled pupil response shows significant dynamic circadian changes under controlled illumination and stimulus irradiance for both 488 nm and 610 nm stimuli (p<0.001; mixed model univariate ANOVA).
The average sample data revealed a small, albeit significant decrease in maximum pupil constriction at a rate of 0.012 mm.h−1 and 0.011 mm.h−1 for the 488 nm and the 610 nm lights respectively (p≤0.001; mixed model univariate ANOVA).
Similar(53)
For all continuous variables, a mixed model of univariate repeated measurements was used to analyse the within-group time dependence.
Table 3 summarizes the association between the different case-mix variables, the stages of endometriosis, and surgical outcomes, using the mixed model regression analysis (univariate and multivariate analysis).
Univariate mixed model regression analyses compared between-group volume differences.
The data for growth traits were analyzed using a univariate mixed model to estimate breeding values, variance components and response to selection.
Although for each animal, it is assumed that the haplotypes are independent from each other; therefore n univariate mixed model analyses can be performed.
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