The rightmost column shows the results from linear mixed models, with diagnostic categories, current antipsychotic medication use, metabolic comorbidity (that is, type 2 diabetes, metabolic syndrome, and obesity (body mass index ≥30)), diet (use of vegetable oil versus butter, use of milk and cheese with high fat content, daily use of vegetables) and hours of fasting.
However, diagnostics of the mixed model indicated a very nonnormal distribution of residuals.
Model diagnostics from linear mixed effects models showed that residuals were skewed and an inverse transformation was applied to the ERI values.
The use of differentiated models for capitation and medicine payments is based on the findings of Zhao et al. [ 28], who give better predictive power for future prescription drug costs for mixed models that combine diagnostic and drug use data.
We show that standard regression diagnostics available in common linear mixed model packages can be used to detect and locate inconsistency in trial networks.
From this analysis, we can obtain residual and influence diagnostics [ 18, 19] by standard procedures with most linear mixed model packages.
It also embeds the diagnostic meta-analysis problem into the well-known and much used mixed model setting.
Linear and mixed effects regressions using biomarker quartiles as the exposure were selected for the main analysis after model diagnostics were applied to regressions using exposures as continuous variables and substantial violations of key model assumptions were identified.
Also, the choice to analyse the yield (y it ) as a nonlinear mixed model, rather than ln y it ) as a linear mixed model was made on the basis of residual diagnostics.
Generalized linear mixed model.
